Accuracy assessment of pharmacogenetic algorithms for warfarin dose prediction in Chinese patients
نویسندگان
چکیده
منابع مشابه
Evaluation of pharmacogenetic algorithm for warfarin dose requirements in Japanese patients.
BACKGROUND Warfarin dosing is difficult to establish because of considerable interindividual variation. Thus, warfarin pharmacogenetics have attracted particular interest in relation to appropriate control of anticoagulation. METHODS AND RESULTS The 200 eligible subjects were chosen from participants in a hospital cohort. Performance of a pharmacogenetic algorithm recently developed by the In...
متن کاملFactors determining the maintenance dose of warfarin in Chinese patients.
Chinese patients are reportedly more sensitive than Caucasians to the anticoagulant effect of warfarin. We examined warfarin dose requirements and their determinants in 151 Chinese out-patients on stable maintenance dose of warfarin with international normalized ratio of 2 to 2.5. Mean daily warfarin requirement was 3.3 +/- 1.4 mg, much lower than reported doses in Caucasian patients. The most ...
متن کاملEstimation of the Warfarin Dose with Clinical and Pharmacogenetic Data
Copyright © 2009 Massachusetts Medical Society. Background Genetic variability among patients plays an important role in determining the dose of warfarin that should be used when oral anticoagulation is initiated, but practical methods of using genetic information have not been evaluated in a diverse and large population. We developed and used an algorithm for estimating the appropriate warfari...
متن کاملEstimation of the Warfarin Dose with Clinical and Pharmacogenetic Data
Copyright © 2009 Massachusetts Medical Society. Background Genetic variability among patients plays an important role in determining the dose of warfarin that should be used when oral anticoagulation is initiated, but practical methods of using genetic information have not been evaluated in a diverse and large population. We developed and used an algorithm for estimating the appropriate warfari...
متن کاملEstimation of the warfarin dose with clinical and pharmacogenetic data.
BACKGROUND Genetic variability among patients plays an important role in determining the dose of warfarin that should be used when oral anticoagulation is initiated, but practical methods of using genetic information have not been evaluated in a diverse and large population. We developed and used an algorithm for estimating the appropriate warfarin dose that is based on both clinical and geneti...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2012
ISSN: 0361-8609
DOI: 10.1002/ajh.23151